Health Care

By: Tarun Gupta

Ephedrine is a sympathomimatic amine derived from a shrub like plant called Ephedra, especially Ephedra sinica, which is found in desert regions in central Asia and other parts of the world and is famous for its dried greens which have medicinal properties. Ephedra’s main active medical ingredients are the alkaloids ephedrine and pseudo-ephedrine and the Ephedrine is most usually marketed in the hydrochloride and sulfate forms.

Therapeutic properties of Ephedrine:

Ephedrine is a white odorless powdered or crystalline alkaloid commonly used as stimulant, appetite suppressant, concentration aid, decongestant, and to treat hypotension associated with anesthesia. It is an FDA-regulated drug commonly prescribed as a bronchodilator to treat bronchitis and asthma.

Ephedrine is also frequently used intravenously in the reversal of hypotension from spinal/epidural anesthesia. It is also used in other hypotensive states, including overdose with ganglionic blocking agents, anti-adrenergic agents, or other medications that lower blood pressure.

Mechanism of Action: Principally, Ephedrine acts direct or indirectly on the adrenergic receptor system which is a part of the sympathetic nervous system (SNS). CNS is also involved to some extent; however, the predominant clinical effects are caused by involvement with the sympathetic segment of the peripheral nervous system.

Side Effects of Ephedrine: Various adverse reactions or side effects of Ephedrine have been found to be more common with systemic administration of the drug, for instance, intravenous injection or oral administration as compared to topical administration like nasal instillations. Some of the side effects associated with steroid abuse include, but are not limited to:

• Cardiovascular: Ephedrine may lead to tachycardia (i.e. abnormally rapid heartbeat), cardiac arrhythmias, angina pectoris i.e. a heart condition marked by paroxysms of chest pain due to reduced oxygen to the heart, and vasoconstriction with hypertension.

• Genitourinary: There may be an increased urine output due to increased blood flow while there may also be some difficulty in urinating as alpha-agonists such as ephedrine constrict the internal urethral sphincter.

• Neuro-muscular Complications: Ephedrine may lead to restlessness, confusion, insomnia, and mild euphoria. In extreme cases, there may be hostility, panic, and/or agitation. Formication, i.e. a form of hallucinated sensation that insects or snakes are crawling over the skin, may also be possible but lacks attested evidence.

A word of Caution: If you have any of the following medical conditions, Ephedrine is not recommended for use: Glaucoma, certain psychiatric conditions, cardio-vascular complications, diabetes, hyperthyroidism, fluctuating blood pressure, and/or any allergies. It is not known whether this drug passes into breast milk or not and due to the potential risk to the infant, breast-feeding while using this drug is not recommended.

Tarun Gupta, the author of Steroid Abuse News & Articles. More information on the subject is at All you need to know about Ephedrine, and resources from other home health and wellness testing sources are used such as Steroid Urine Test Kit.

Article Source: http://www.ArticleBiz.com

By: Charles Kassotis

The thyroid gland does not require extra attention or maintenance most of the time. But when it acts up, you will notice a change in your health marked by relevant symptoms. Although these may be vague enough to avoid your physician’s diagnosis for a time, with the right blood test and a careful medical examination, you can soon find out if you have hypothyroidism.

One of the first reasons to suspect that your thyroid may be acting up is if you feel extra sluggish or worn out. Some people report they get so tired and listless, that it becomes increasingly difficult to get out of bed most days. They can barely drag across the floor to get to the bathroom, and a flight of stairs seems to ask the impossible. Of course, if you get to this point, you need to see a doctor pronto, as your thyroid may be in serious trouble. But be sure to ask your doctor to evaluate any type of unexplained fatigue.

Another symptom is dry skin and hair. You may find that your hair seems thin or brittle, and it could lose its sheen. Your skin may become rough and flaky, no matter how much you try to moisturize it. Like hair, skin can lose its natural vibrancy, tone, and color, especially around the joints like your elbows. Your mouth may feel drier than usual, as well.

Internal organs may not work properly and show signs of problems. For example, you could develop frequent or recurrent constipation. Your periods (if you are a female) could start coming irregularly and may not have the same type of monthly flow that you are used to. Your heart or breathing may not seem to work as efficiently as before. This observation fits with the fatigue mentioned above.

Since many of these symptoms are fairly generic, you will need to see your doctor to get an examination and accurate diagnosis. Your doctor may order blood tests to check the level of your thyroid’s function. You might even be asked to take a radioactive pill or receive an injection that will let a technician check your thyroid’s activity level the next day or so. Be sure to follow directions and keep pets or children away for a day or two afterward until the radioactive matter passes from your body.

If the doctor makes a diagnosis of hypothyroidism, you will probably be given a prescription medication to supplement the work your thyroid is supposed to do. Most of the time this condition is permanent, and it could be serious or even fatal if you don’t take the medication. That is why it is important to check with your doctor about any problems you may be having so you can get a speedy and correct diagnosis and treatment. If you have the opposite kind of symptoms, such as a racing heart rate, oily skin, and diarrhea, you could have hyperthyroidism or another condition. Always let your doctor know if you experience a significant change in bodily behavior.

Learn how to easily recognize the common symptoms of hypothyroidism.
For more information on the warning signs of hypothyroidism, Visit The Thyroid Organization

Article Source: http://www.eArticlesOnline.com

From Mary Shomon,

Hypothyroidism, Hyperthyroidism, Thyroiditis, Nodules, Goiter, Thyroid Cancer

HYPOTHYROIDISM/HASHIMOTO'S DISEASE

Some practitioners believe that Hashimoto’s, which can be confirmed by testing for thyroid antibodies, warrants treatment in some patients. There is some evidence that treating Hashimoto’s disease with thyroid hormone replacement drugs before the thyroid stimulating hormone (TSH) level rises may alleviate some symptoms. Some research suggests that treating someone with Hashimoto’s but a normal TSH may help prevent elevation of the TSH level and progression to full hypothyroidism. This is discussed further in Treating Hashimoto's When the TSH is Normal.

On the integrative medicine front, some holistic practitioners recommend iodine supplementation, other nutritional supplements, dietary changes, particular yoga poses, mind-body medicine, and other complementary approaches to help the thyroid.

HYPERTHYROIDISM / GRAVES’ DISEASE

Hyperthyroidism is treated by reducing the excess hormone levels, which is accomplished in three different ways:

• antithyroid drugs
• radioactive iodine treatment (RAI), also known as radioiodine ablation
• surgical removal of all or part of the thyroid, known as thyroidectomy
• block/replace therapy (BRT)
• thyroid arterial embolization

Interest is also growing in thyroid arterial embolization, a new approach for Graves' disease treatment.

In some cases, key hyperthyroidism symptoms such as rapid heart rate or elevated blood pressure are also treated with drugs known as beta-blockers.

Most thyroid patients who receive RAI treatment or have surgery eventually end up hypothyroid, and are treated with thyroid hormone replacement drugs.

Some integrative practitioners recommend stress reduction programs, antithyroid dietary and nutritional changes, traditional Chinese medicine, and other holistic approaches to help an overactive thyroid.

THYROID STORM

THYROIDITIS

As noted, in some cases, Hashimoto’s thyroiditis is treated with thyroid hormone replacement drugs. For cases of thyroiditis that are painful, doctors typically recommend a pain-reliever with anti-inflammatory properties, such as aspirin, ibuprofen (Advil/Motrin), or naproxen (Aleve).

If the thyroiditis is especially acute, doctors occasionally recommend steroid drugs to reduce inflammation, along with thyroid hormone replacement drugs, to allow the thyroid to rest from its job of hormone production.

Holistic practitioner Stephen Langer, M.D., has shared his recommendations regarding nutritional supplements helpful in treating thyroiditis.

On the nutritional front, there is some evidence that supplementing with the mineral selenium may help thyroiditis.

GOITER

A goiter can cause a variety of symptoms, including a feeling of fullness in the neck, pain, and less commonly, may wrap around the trachea, making it difficult to swallow or even breathe.

For a small, symptomatic goiter, doctors typically treat with thyroid hormone replacement drugs. The drugs can slow down or stop the growth of the goiter in some cases, but they don’t typically shrink the goiter.

If the goiter is large, continues to grow while on thyroid hormone, is cosmetically unsightly, or symptoms continue or worsen, doctors may recommend radioactive iodine (RAI) to shrink the gland, or surgery to remove it all or in part.

In some cases, goiter can be due to iodine deficiency, in which case, doctors may recommend use of iodine supplementation.

THYROID NODULES

The thyroid is almost always surgically removed all or in part when cancerous or indeterminate nodules are detected. In the case of malignancy, thyroid cancer treatment protocols are followed, based on the type of cancer detected.

For small, benign nodules that cause no symptoms, many practitioners prefer to monitor patients. A substantial percentage of the population – some experts suggest the majority of people – have these asymptomatic nodules, and require no further treatment.

For symptomatic benign nodules, the first course of treatment is frequently the thyroid hormone replacement drug levothyroxine, which can sometimes shrink the nodule, prevent nodules from growing, and help prevent more nodules from forming. Because the treatment is fully effective in only a minority of patients, levothyroxine therapy is considered somewhat controversial.

If the benign nodule is larger and unresponsive to drug or radioactive iodine treatment, surgery is often recommended.

Another approach being used for nodules is Percutaneous Ethanol Injection (PEI), where the nodule is shrunk by an injection.

Another promising new non-surgical technology for nodules is high-intensity ultrasound beam technology.

Detailed guidelines on treatment for nodules are featured in the American Association of Clinical Endocrinologists’ Medical Guidelines for Clinical Practice for the Diagnosis and Management of Thyroid Nodules.

THYROID CANCER

The treatments for thyroid cancer include:

• Surgery to remove the cancer, known as a thyroidectomy. Some patients receive a lobectomy, which removes only one side of the thyroid. A near-total thyroidectomy removes almost all of the gland. The entire thyroid is removed in a total thyroidectomy. Lymph node dissection is also sometimes performed during thyroid surgery, to assess the spread of thyroid cancer.

• Radiation therapy to kill cancer cells. Radiation can be delivered outside the body (known as external beam radiation) or by radioactive iodine (RAI), which is usually administered as a liquid or pill. The thyroid absorbs iodine, and the radioactive form of iodine collects in thyroid tissue and kills cancer cells.

• Hormone therapy, using thyroid hormone replacement drugs. Administering thyroid hormone, usually at suppressive doses to keep TSH low or undetectable, helps prevent thyroid cancer from recurring, by suppressing the activity of any residual thyroid tissue.

• Chemotherapy, which uses drugs to kill cancer cells. It may be taken in pill form, or intravenously.

Treatment for medullary thyroid cancer typically includes total thyroidectomy, and in some cases, lymph nodes are also removed. In the later stages of medullary thyroid cancer, radiation therapy to shrink tumors is used to help relieve symptoms and improve quality of life. In late stage medullary cancer, chemotherapy may be recommended to help relieve symptoms.

Treatment for anaplastic thyroid cancer can include the following: tracheostomy surgery to create an opening in the windpipe (done for tumors that interfere with breathing); total thyroidectomy to reduce symptoms; external-beam radiation therapy; chemotherapy; and clinical trials studying new therapies.

Some new therapies for thyroid cancer are currently in investigational or trial status, including the drug axitinib, combretastatin, and lenalidomide.

Detailed guidelines on treatment of thyroid cancer are featured in the Thyroid Cancer Guidelines from the American Thyroid Association (2006).

Mary Shomon, About.com's Thyroid Guide since 1997, is a nationally-known patient advocate and best-selling author of 10 books on health, including "The Thyroid Hormone Breakthrough: Overcoming Sexual and Hormonal Problems at Every Age," "The Thyroid Diet: Manage Your Metabolism for Lasting Weight Loss," "Living Well With Hypothyroidism: What Your Doctor Doesn't Tell You...That You Need to Know," "Living Well With Graves' Disease and Hyperthyroidism," "Living Well With Autoimmune Disease," and "Living Well With Chronic Fatigue Syndrome and Fibromyalgia." Click here for more information on Mary Shomon.

source:about.com